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fAUC/MIC associated with EI80, EI50, and stasis values for tigecycline against all S. aureus isolates in the neutropenic thigh model
| Isolate |
fAUC/MIC
|
Maximum change in log10 CFU/ml | ||
|---|---|---|---|---|
| EI80 | EI50 | Stasis | ||
| MSSA ATCC 29213 | 4.1 | 0.6 | 0.5 | 2.3 |
| MSSA ATCC 25923 | 7.0 | 5.0 | 5.3 | 1.4 |
| HA-MRSA 56 | 4.2 | 2.5 | 2.5 | 2.0 |
| HA-MRSA 152 | 2.8 | 1.5 | 1.6 | 1.8 |
| CA-MRSA 144 | 3.2 | 2.2 | 2.6 | 1.4 |
| CA-MRSA 147 | 3.5 | 1.5 | 1.7 | 1.8 |
| CA-MRSA 156 | 13.0 | 5.1 | 5.3 | 2.1 |
