TABLE 2.
Values of pharmacokinetic parameters for the drugs tested in cage fluid after administration of a single intraperitoneal dose to noninfected animals
| Antibiotic | Dose (mg/kg) | Cmax (μg/ml)a | Cmin (μg/ml)a | Tmax (h)a | t1/2 (h)a | AUC0-24 (μg·h/ml)a | Cmaxb/MIC | AUC0-24b/MIC (h) |
|---|---|---|---|---|---|---|---|---|
| Linezolid | 25 | 6.8 ± 1.3 | 3.0 ± 0.2 | 3.0 ± 0.4 | 6.8 ± 1.7 | 87.8 ± 2.7 | 2.7 | 35.1 |
| Linezolid | 50 | 12.7 ± 2.2 | 3.7 ± 1.1 | 3.3 ± 0.2 | 3.5 ± 1.7 | 118.7 ± 23.0 | 5.1 | 47.5 |
| Linezolid | 75 | 18.1 ± 1.7 | 2.5 ± 1.0 | 2.8 ± 0.2 | 2.6 ± 0.9 | 125.8 ± 20.5 | 7.2 | 50.3 |
| Rifampin | 12.5 | 1.0 ± 0.3 | 0.1 ± 0.1 | 2.1 ± 0.3 | 2.5 ± 1.3 | 4.6 ± 0.5 | 100.0 | 460 |
| Levofloxacin | 10 | 1.5 ± 0.2 | 0.3 ± 0.1 | 2.5 ± 0.3 | 4.2 ± 1.4 | 6.1 ± 0.8 | 9.4 | 38.1 |
a
Values are means ± SDs from three animals, as predicted by use of the WinNonlin software package.