TABLE 3.
Counts of planktonic bacteria in cage fluid and rate of culture-negative cage fluid samples during treatment (day 4) and 5 days after end of treatment (day 10)
| Treatment group, dose (mg/kg) | Bacterial counts in cage fluid (log10 CFU/ml)a
|
No. of culture-negative cage fluid samples/total no. of samples (%)
|
||
|---|---|---|---|---|
| Day 4 | Day 10 | Day 4 | Day 10 | |
| Control (12)b | 7.1 (7.0-7.5) | 7.9 (7.6-8.1) | 0/12 (0) | 0/12 (0) |
| Linezolid, 25 (12) | 4.5 (4.1-5.0) | 7.3 (7.1-7.7) | 1/12 (8) | 0/12 (0) |
| Linezolid, 50 (12) | 5.1 (4.1-6.0) | 7.1 (6.8-8.0) | 2/12 (17) | 0/12 (0) |
| Linezolid, 75 (12) | 4.6 (3.2-5.0) | 4.5 (4.0-5.2) | 3/12 (25) | 2/12 (17) |
| Rifampin, 12.5 (12) | 3.1 (3.0-3.4) | <3.0 | 6/12 (50) | 11/12 (92) |
| Linezolid, 25, + rifampin, 12.5 (20) | <3.0 | <3.0 | 13/20 (65) | 19/20 (95) |
| Linezolid, 50, + rifampin, 12.5 (20) | <3.0 | <3.0 | 13/20 (65) | 15/20 (75) |
| Linezolid, 75, + rifampin, 12.5 (20) | <3.0 | <3.0 | 11/20 (55) | 17/20 (85) |
| Levofloxacin, 10, + rifampin, 12.5 (24) | <3.0 | <3.0 | 18/24 (75) | 11/11 (100) |
a
Values are medians (interquartile ranges).
b
Values in parentheses in this column are the number of cages.