TABLE 1.
Baseline patient characteristics
| Characteristic | No. (%) of patients with characteristic
|
||
|---|---|---|---|
| Single dose of caspofungin (25 mg/m2) (n = 6) | Multiple doses of caspofungin (25 mg/m2) (n = 12) | Total (n = 18) | |
| Gender | |||
| Male | 3 (50.0) | 9 (75.0) | 12 (66.7) |
| Female | 3 (50.0) | 3 (25.0) | 6 (33.3) |
| Race | |||
| American Indian or Alaska Native | 0 (0.0) | 1 (8.3) | 1 (5.6) |
| Asian | 2 (33.3) | 2 (16.7) | 4 (22.2) |
| Black, of African heritage | 0 (0.0) | 1 (8.3) | 1 (5.6) |
| Multiracial | 4 (66.7) | 8 (66.7) | 12 (66.7) |
| Gestational age at birth (wk) | |||
| <28 | 1 (16.7) | 0 (0.0) | 1 (5.6) |
| 28 to 31 | 4 (66.7) | 4 (33.3) | 8 (44.4) |
| 32 to 36 | 1 (16.7) | 3 (25.0) | 4 (22.2) |
| >36 | 0 (0.0) | 5 (41.7) | 5 (27.8) |
| Chronological age (wk) | |||
| ≤2 | 3 (50.0) | 2 (16.7) | 5 (27.8) |
| 3 to 4 | 0 (0.0) | 7 (58.3) | 7 (38.9) |
| 5 to 8 | 3 (50.0) | 1 (8.3) | 4 (22.2) |
| 9 to 12 | 0 (0.0) | 2 (16.7) | 2 (11.1) |
| Mean | 3.8 | 4.9 | 4.6 |
| Median | 3.5 | 4.0 | 4.0 |
| Range | 1-7 | 2-11 | 1-11 |
| Weight at enrollment (kg) | |||
| ≤1 | 2 (33.3) | 2 (16.7) | 4 (22.2) |
| 1.01 to 1.50 | 1 (16.7) | 2 (16.7) | 3 (16.7) |
| 1.51 to 2.00 | 1 (16.7) | 1 (8.3) | 2 (11.1) |
| 2.01 to 2.50 | 1 (16.7) | 2 (16.7) | 3 (16.7) |
| >2.50 | 1 (16.7) | 5 (41.7) | 6 (33.3) |
| Invasive Candida infection | |||
| Documented | 2 (33.3) | 6 (50.0) | 8 (44.4) |
| Highly suspected | 4 (66.7) | 6 (50.0) | 10 (55.6) |