TABLE 2.
Caspofungin plasma concentrations in neonates/infants of <3 months of age and adults with esophageal/oropharyngeal candidiasis or invasive candidiasis
| Disease, day, and parameter | Neonates and infants
|
Historical adult patients
|
Ratio (neonates and infants/adults)
|
|||||
|---|---|---|---|---|---|---|---|---|
| n | GMa | 95% CI | n | GMa | 95% CI | GMR | 90% CI | |
| Esophageal/oropharyngeal candidiasis | ||||||||
| Day 1 | ||||||||
| C1 h | 18 | 8.2 | 6.8, 10.0 | 38 | 7.7 | 6.7, 8.7 | 1.07 | 0.89, 1.30 |
| C24 h | 18 | 1.8 | 1.4, 2.4 | 33 | 1.3 | 1.1, 1.6 | 1.36 | 1.04, 1.78 |
| Day 4b | ||||||||
| C1 h | 12 | 11.1 | 8.8, 13.9 | 38 | 9.4 | 8.2, 10.7 | 1.18 | 0.95, 1.46 |
| C24 h | 11 | 2.4 | 1.8, 3.4 | 60 | 2.0 | 1.7, 2.3 | 1.21 | 0.90, 1.63 |
| Invasive candidiasis | ||||||||
| Day 4b | ||||||||
| C1 h | 12 | 10.9 | 8.2, 14.6 | 86 | 7.0 | 6.3, 7.8 | 1.56 | 1.21, 2.01 |
| C24 h | 11 | 2.3 | 1.6, 3.5 | 90 | 1.5 | 1.3, 1.8 | 1.53 | 1.09, 2.17 |
a
Geometric mean, based on least-squares mean from a mixed-effect model performed on natural-log-transformed values.
b
For the adult patients, day 4 values were calculated by time averaging data for days 3 to 14.