TABLE 1.

Body weight and PCV changes in vervet monkeys infected with T. brucei rhodesiense and treated with different regimens of pafuramidine

Group (dose [mg/kg])	Mean preinfection wt (kg) ± SE	% Wt change ata:			Mean preinfection % PCV ± SE	% Change in PCV ata:
		Day 0 p.t.b	Day 28 p.t.c	End point		Day 0 p.t.b	Day 28 p.t.c	End point
1 (1)	3.15 ± 0.45	−2.20	−2.1d	0	47.0 ± 4.4	−4.30	−17.0d	−23.40
2 (3)	3.18 ± 0.33	−5.00	−6.60	−1.60	46.0 ± 4.4	−9.40	−2.90	−3.60
3 (10)	2.88 ± 0.43	−6.30	0	3.50	40.3 ± 2.5	−5.80	−1.60	13.20
4 (10)	4.25 ± 0.52	−4.20	−5.20	−0.70	51.7 ± 6.1	−25.80	−13.50	−7.70
5 (10)	3.32 ± 0.60	−10.50	−8.10	−2.10	47.7 ± 1.5	−41.30	−9.10	1.40

^aPercent change in body weight or PCV from preinfection values. A − indicates a decline.

^bValues taken before the first treatment dose, i.e., on the 7th day p.i. for groups 1 to 3, 14th day p.i. for group 4, and 28th day p.i. for group 5.

^cData for groups 2 to 5 at 28 days p.t.

^dPercent change in body weight and PCV at 1 day p.t. for group 1.