TABLE 2.
Outcomes of treatment of T. brucei rhodesiense-infected vervet monkeys with different regimens of pafuramidine (DB289)a
| Group | Dose (mg/kg) (length of treatment [days]) | Monkey | Time to detection of trypanosomes in biological fluids (days p.t.)
|
No. of cured monkeys/no. of total monkeys | |||
|---|---|---|---|---|---|---|---|
| Blood
|
CSF
|
||||||
| MIT | WS + HCT | MIT | HC + CT | ||||
| 1 | 1 (5) | 463 | 7 | 9 | NC | NC | 0/3 |
| 484 | NC | 4 | 7 | 14 | |||
| 485 | 3 | 14 | 21 | ||||
| 2 | 3 (5) | 482 | 55 | 79 | 21 | 1/3 | |
| 483 | 69 | 66 | 69 | 55 | |||
| 411 | Cured | ||||||
| 3 | 10 (5) | 454 | Cured | 3/3 | |||
| 468 | Cured | ||||||
| 486 | Cured | ||||||
| 4 | 10 (5) | 471 | 56 | 87 | NC | NC | 1/3 |
| 478 | Cured | ||||||
| 488 | ND | 42 | ND | ||||
| 5 | 10 (10) | 490 | ND | 21 | 42 | 0/3 | |
| 501 | 56 | 73 | NC | ||||
| 520 | ND | 119 | 119 | ||||
a
ND, not detected for >180 days p.t.; WS, wet smear; HC, hemocytometer counting; CT, concentration techniques for CSF; NC, trypanosome not cleared.