TABLE 4.
Neonatal parameters estimated for administrations of 0, 1, 2, and 3 mg FTC/kg 1 h after birth and 2 mg/kg 12 h after birth (TEmAA ANRS 12109 trial, step 1)
| Dose (mg/kg)b | Median value
|
||
|---|---|---|---|
| AUC0→24 (mg/liter·h) | Cmin (mg/liter) | Timea (h) | |
| 0 | 8.2 | ||
| 1 (1) | 10.1 | 0.67 | 36.6 |
| 2 (1) | 11.9 | 0.67 | 40.2 |
| 3 (1) | 13.4 | 0.67 | 42.8 |
| 2 (12) | 10.5 | 0.31 | 33.9 |
a
Time during which neonatal concentrations remained >0.077 mg/liter.
b
Numbers in parentheses indicate the number of hours after birth at which the dose was administered.