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. 2008 Dec 22;53(3):967–976. doi: 10.1128/AAC.00939-08

FIG. 2.

FIG. 2.

Antiviral effect of the combination of Debio 025 with RBV (A), the protease inhibitor VX-950 (B), the NI 2′-C-MeCyt (C), or the NNI JT-16 (D) in HuH6 cells. The zero plane on the z axis represents an additive effect, the volume above the zero plane indicates synergistic activity, and the volume below the zero plane indicates an antagonistic effect. The different shades represent different ranges of values: black, −20% to 0%; gray, 0% to 20%; dashed line, 20% to 40%. Data for the combinations Debio 025-RBV and Debio 025-2′-C-MeCyt are mean values for three independent experiments; data for the combinations of Debio 025-VX-950 and Debio 025-JT-16 are mean values for two independent experiments.