TABLE 2.
MICs of β-lactams for B. cepacia complex isolates 07-34, 09-54, 212, and 5007902; E. coli TOP10 harboring recombinant plasmid pBcSau13 expressing the PenB1 β-lactamase; and the E. coli TOP10 reference strain
| β-Lactam(s)a | MIC (μg/ml)
|
|||||
|---|---|---|---|---|---|---|
| B. cenocepacia 07-34 (PenB1) | B. cenocepacia 09-54 (PenB2) | B. cenocepacia 212 (PenB3) | B. cenocepacia 5007902 (PenB4) | E. coli TOP10(pBcSau13) (PenB1) | E. coli TOP10 | |
| Amoxicillin | 512 | 512 | 512 | 512 | 512 | 4 |
| Amoxicillin+ CLA | 512 | 512 | 512 | 512 | 16 | 4 |
| Ticarcillin | 512 | 512 | 512 | 512 | 512 | 4 |
| Piperacillin | 4 | 512 | 128 | 4 | 8 | 2 |
| Piperacillin + TZB | 4 | 256 | 128 | 4 | 4 | 2 |
| Cefuroxime | 16 | 512 | 512 | 32 | 16 | 8 |
| Ceftazidime | 4 | 32 | 16 | 0.25 | 1 | 0.5 |
| Cefotaxime | 1 | 512 | 512 | 4 | 0.25 | 0.06 |
| Cefepime | 32 | 64 | 64 | 1 | 0.125 | 0.06 |
| Cefoxitin | 512 | 512 | 512 | 512 | 8 | 8 |
| Aztreonam | 4 | 512 | 512 | 16 | 0.5 | 0.06 |
| Imipenem | 8 | 16 | 16 | 8 | 0.5 | 0.25 |
a
CLA, clavulanic acid at a fixed concentration of 4 mg/ml; TZB, tazobactam at a fixed concentration of 4 mg/ml.