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Mefloquine resistance reversal by ellagic acid. Values are the means of three independent experiments. (a) Means of reversal concentrations of penfluridol (positive control) for mefloquine-resistant strain Dd2 (CR50 for penfluridol of 96 ± 7 ng/ml). (b) Means of reversal concentrations of ellagic acid for mefloquine-resistant strain Dd2 (CR50 for ellagic acid of 5 ± 4 ng/ml). (c) Absence of reversion by ellagic acid for mefloquine-sensitive strain FcM29 (negative control).
