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. 2009 Feb 10;5:5. doi: 10.1186/1744-8069-5-5

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Copyright © 2009 Cao et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Enhancement of 4α-PDD-induced increase in synaptic transmission by PDBu in cultured hippocampal neurons. A. Application of 4α-PDD (10 μM) increases the frequency of mEPSCs, which is further potentiated by PDBu. The synaptic events are shown at a higher time resolution below. B. Cumulative probability plot shows a decrease in inter-event interval. C. The increase in frequency is not accompanied by a change in the amplitude. D. Summary graph showing 4α-PDD induces an increase in mEPSC frequency and this action is enhanced by PDBu (n = 7). The asterisk (*) represents P < 0.05 as compared to control; (**) represents P < 0.05 as compared to 4α-PDD group.