Table 1.
Mutations identified in 224 INH resistant M. tuberculosis isolates from South America
| Specific mutation in each loci (number of isolates with mutation) | |||||||
|---|---|---|---|---|---|---|---|
| katG only | OxyR-ahpC only | inhA (reg) only | inhA (ORF) only | KatG and inhA (reg) | KatG and ahpC | No mutation* | |
| Brazil (176) |
S315T (121) S315N (5) S315I (3) G258D*** (1) |
C(-15)T (1) I20I (1)**/*** C(-39)T (3) C(-30)T (1) G(-6)A (2) G(-32)A (1) |
C(-15)T (7) | G(82)R*** (1) | W300R***/C(-15)T (1) S315T/C(-15)T (8) |
S315N/I20I**/*** (1) G299S/G(-9)A (1) S315T/G(-48)A (1) |
17 |
| Peru (34) |
S315T (19) S315N (2) |
C(-10)T (1) | C(-15)T (3) | S(94) R*** (1) | S315T/C(-15)T (1) | S315N/C(-10)A*** (1) S315T/C(-10)A*** (3) S315T/C(-15)T (1) |
2 |
| Argentina (14) |
S315T (9) | C(-15)T (1) C(-10)T (1) |
--- | S(93)A*** (1) | S315T/C(-15)T (1) | --- | 1 |
| Total 224 | N = 160 | N = 12 | N = 10 | N = 3 | N = 11 | N = 8 | N = 20 |
*No mutation in studied loci.
**Silent mutation in the codon 20 of the ahpC gene.
***Not reported in the literature.