Figure 4.

TRAIL and radiotherapy, in combination, induce regression and slow the growth of breast cancer xenografts. NIH III nude mice harboring MCF7 xenograft tumors were treated with saline, TRAIL (5 mg/kg for 7 days), RT (radiotherapy, three 5-Gy fractions), or a combination of TRAIL and RT. Mean tumor volumes were calculated 15 days after the start of treatment and are expressed as a percent change in tumor volume (A). Similarly, mean tumor volumes were assessed 2–3 times a week for over 4 weeks and are expressed in relation to the starting tumor volume (B). Six to ten xenografts were used in each experiment, and the data shown is derived from the mean volume ± SEM.