Table 1.
Sensitivity of various human cell lines to TRAIL-induced apoptosis
| Breast cell lines | |
| SUM149 | ++++++ |
| SUM229 | ++++++ |
| MCF10A | +++++ |
| SUM102 | ++++ |
| SUM44 | + |
| MCF7 | + |
| SUM185 | + |
| SUM131/5MD2 | + |
| SUM52 | + |
| SUM225 | + |
| SUM190 | − |
| Normal HME | − |
| Other cell lines | |
| HT29 (colon cancer) | + |
| A549 (lung cancer) | − |
| UMSCCVI (squamous cancer) | ++ |
| 293T | − |
| HCT 116 ( ) | ++ |
| Glial U251 | +++++ |
| DU145 (prostate cancer) | + |
Cell lines were assessed for apoptosis based on morphologic criteria. Relative apoptosis is represented whereby 6+ equals >95% apoptosis after overnight incubation with saturating doses of TRAIL (1,000 ng/ml). 3+ equals ∼50% apoptosis. 1+ equals approximately 10% apoptosis, and − represents virtually complete resistance to TRAIL.