Table 3.
Association of rs2187331 and rs3181041 with logTGs in METSIM study.
| SNP | Minor | MAF | Mean TG by Genotype±SD mmol/L (n)A |
Allelic | Allelic | Genotypic | ||
|---|---|---|---|---|---|---|---|---|
| Allele | 11 | 12 | 22 | p-valueB | Effect Size±s.e.m.C | p-valueB | ||
| All (n=4,463) | ||||||||
| rs2187331 | C | 0.09 | 1.46±0.98 (3,658) | 1.55±1.62 (766) | 2.22±2.33 (38) | 0.0028 | 0.108±0.036 | 0.00016 |
| rs3181041 | C | 0.08 | 1.48±1.18 (3,742) | 1.46±0.87 (700) | 1.33±0.58 (21) | ns | 0.006±0.039 | ns |
| Non-statin users (n=3,963) | ||||||||
| rs2187331 | C | 0.09 | 1.44±0.98 (3,250) | 1.49±0.94 (678) | 2.00±2.30 (34) | 0.026 | 0.086±0.038 | 0.019 |
| rs3181041 | C | 0.08 | 1.46±1.02 (3,330) | 1.43±0.83 (615) | 1.30±0.56 (18) | ns | −0.017±0.041 | ns |
| Statin users (n=497) | ||||||||
| rs2187331 | C | 0.1 | 1.56±0.97 (405) | 1.99±4.01 (88) | 4.09±1.99 (4) | ns | 0.122±0.076 | ns |
| rs3181041 | C | 0.09 | 1.64±2.05 (411) | 1.71±1.11 (84) | 1.63±0.93 (2) | ns | −0.002±0.081 | ns |
| Non-diabetics (Fasting glucose<7mmol/L, n=3,802) | ||||||||
| rs2187331 | C | 0.09 | 1.38±0.91 (3,134) | 1.46±1.64 (635) | 2.34±2.48 (33) | 0.0013 | 0.12±0.038 | 0.000012 |
| rs3181041 | C | 0.08 | 1.40±1.13 (3,199) | 1.38±0.85 (585) | 1.33±0.60 (18) | ns | −0.006±0.041 | ns |
| Diabetics (Fasting glucose≥7mmol/L, n=658) | ||||||||
| rs2187331 | C | 0.11 | 1.89±1.23 (522) | 1.95±1.47 (131) | 1.42±0.33 (5) | ns | −0.010±0.108 | ns |
| rs3181041 | C | 0.09 | 1.90±1.35 (543) | 1.88±0.88 (114) | 1.37 (1) | ns | 0.048±0.116 | ns |
A
1 is the major allele, and 2 is the minor allele.
B
Analyses were conducted in R using linear regression with standardized log10 TG adjusting for the covariates age, BMI, smoking status (smoking or not). When n was <10 in the rare allele homozygote group, the heterozygotes and rare allele homozygotes were combined.
ns indicates p-values >0.1.
C
Allelic effect size is given as the beta-coefficient (β), which represents the proportion of 1 standard deviation change.