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. Author manuscript; available in PMC: 2009 Mar 4.
Published in final edited form as: Circ Res. 2008 Jul 25;103(5):493–501. doi: 10.1161/CIRCRESAHA.108.181487

Figure 3. FOG-2 mice ventricles show fetal gene expression pattern including repression of SERCA2.

Figure 3

(a) Fold difference of BNP, βMHC and αMHC and SERCA2 mRNA transcripts, each normalized to GAPDH mRNA in 4–6 wk old FOG-2-high Tg mice (n=4) relative to NTg littermate controls (n=4) measured by qRT-PCR. (b) Immunoblot analysis of SERCA2, CSQ and GAPDH protein in ventricular myocardium from FOG-2-high Tg mice. SERCA2 band density normalized to CSQ. (c) Increased SERCA2 protein and reduced FOG-2 protein seen in FOG-2 heterozygote null ventricles. Unpaired t-test, *, p<0.05 versus NTg.