TABLE 1.
Response to a primary series of the PCV7 of 31 infants for vaccine-type serotypes and VRTs 19A and 6A evaluated by antibody concentrations and opsonic activity
Assay | Parametera | PCV7 vaccine-type serotypes
|
VRTs
|
|||||||
---|---|---|---|---|---|---|---|---|---|---|
4 | 6B | 9V | 14 | 18C | 19F | 23F | 19A | 6A | ||
ELISA | GMC (μg/ml) | 3.93 | 4.75 | 3.19 | 10.49 | 3.86 | 3.79 | 2.98 | 1.84 | NDb |
95% CI | 2.98-5.17 | 3.24-6.95 | 2.41-4.22 | 7.46-14.74 | 2.77-5.37 | 2.97-4.85 | 2.11-4.19 | 1.43-2.35 | ND | |
Amt (%) ≥ 0.35 μg/ml | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | ND | |
OPA | GMI | 905 | 1,394 | 456 | 3,245 | 810 | 360 | 1,486 | 7 | 83 |
95% CI | 364-1,285 | 907-2,140 | 295-706 | 2,087-5,045 | 582-1,126 | 267-547 | 898-2,460 | 4-11 | 42-164 | |
Amt (%) ≥ 8 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 19.4 | 81 |
GMC, geometric mean concentration; GMI, geometric mean index.
ND, not done.