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. 2009 Mar;73(1):71–133. doi: 10.1128/MMBR.00021-08

FIG. 4.

FIG. 4.

Proposed pathway for anaerobic catabolism of 3-hydroxybenzoate in T. aromatica and Azoarcus sp. strain EbN1. (A) Enzymatic reactions of the 3-hydroxybenzoate catabolic pathway. Enzymes are 3-hydroxybenzoate-CoA ligase (HbcL) and 3-hydroxybenzoyl-CoA reductase (putative HbrABCD in Azoarcus sp. strain EbN1 and BcrABCD in T. aromatica). Further reactions of the pathway are predicted solely from the presence of the corresponding genes in the cluster (the color code of the reactions corresponds to that of the genes in B) (211, 293). (B) Organization of the gene clusters involved in the anaerobic catabolism of 3-hydroxybenzoate in T. aromatica (GenBank accession number AJ278289) (211) and Azoarcus sp. strain EbN1 (accession number NC_006513) (293). Genes are represented by arrows, and their (predicted) functions are indicated by colors as follows: red, 3-hydroxybenzoate-CoA ligases; dark blue, subunits of 3-hydroxybenzoyl-CoA reductase; green, enoyl-CoA hydratases; violet, acyl-CoA dehydrogenases; light blue, hydroxyacyl-CoA dehydrogenases; brown, transporters; gray, gene encoding a BzdT-like protein; black, TetR-like transcriptional regulator.