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. 2009 Mar;73(1):71–133. doi: 10.1128/MMBR.00021-08

FIG. 7.

FIG. 7.

Peripheral pathway for anaerobic catabolism of 4-HBA in anaerobic bacteria. (A) Enzymatic reactions of the pathway as described previously for R. palustris (127) and T. aromatica (40). The following R. palustris (Hba) and T. aromatica (Hcr) enzymes are indicated: HbaA/HcrL, 4-HBA-CoA ligase; HbaBCD/HcrCAB, 4-hydroxybenzoyl-CoA reductase. (B) Organization of the gene clusters involved in anaerobic catabolism of 4-HBA in R. palustris (GenBank accession number NC_005296) and T. aromatica (accession number AJ001830) and those proposed for the genomes of M. magneticum AMB-1 (accession number NC_007626), Azoarcus sp. strain EbN1 (accession number NC_006513), G. metallireducens (accession number NC_007517), and a metagenomic sequence (accession number CR931837). Genes are represented by arrows: red, genes encoding 4-HBA-CoA ligase; green, genes encoding the subunits of 4-hydroxybenzoyl-CoA reductase; black, putative transcriptional regulators; brown, genes encoding putative 4-HBA transporters and/or permeases; yellow, genes encoding a putative maturation factor; white, genes of unknown function. Two vertical lines mean that the genes are not adjacent in the genome.