TABLE 5.
Performances of different CMV assays on the commercially available seroconversion panel RP-003 (Profile Diagnostics)
| Day of sampling | Resulta by the following assay:
|
||||
|---|---|---|---|---|---|
| Architect CMV IgG (IgG concn [AU/ml]) | Architect CMV IgM (IgM index) | Architect CMV IgG Avidity (% avidity) | Radim CMV IgG Avidity (% avidity) | Vidas CMV IgG Avidity (% avidity) | |
| 1 | 8.1 | 1.65 | 1.0 | Invalid | ND |
| 4 | 21.8 | 4.29 | 2.4 | Invalid | 3 |
| 8 | 51.1 | 4.42 | 10.5 | Invalid | 5 |
| 51 | 86.2 | 1.40 | 25.4 | 24.1 | 30 |
| 55 | 94.1 | 1.32 | 24.7 | 31.2 | 31 |
| 59 | 91.2 | 1.42 | 30.4 | 27.9 | 31 |
| 65 | 84.0 | 1.20 | 31.8 | 29.6 | 36 |
| 67 | 85.1 | 1.19 | 32.7 | 30.3 | 36 |
| 72 | 80.8 | 1.12 | 37.9 | 50.2 | 34 |
| 74 | 78.4 | 1.10 | 39.9 | 28.4 | 33 |
| 79 | 80.3 | 1.11 | 40.5 | 31.0 | 38 |
| 84 | 85.1 | 1.11 | 39.4 | 43.3 | 39 |
| 88 | 94.7 | 1.13 | 40.3 | 26.7 | 43 |
| 95 | 87.1 | 1.09 | 45.1 | 45.7 | 39 |
| 99 | 89.4 | 1.03 | 44.9 | 44.1 | 43 |
a
Boldface data represent correct interpretations (with respect to the sensitivity definition for the Architect CMV IgG avidity assay). The cutoff for the Architect CMV IgG assay was a CMV-specific IgG concentration of 6 AU/ml. For the Architect CMV IgM assay, the cutoff was an IgM index of 1.00, and the upper limit of the gray zone was an index of 0.85. For the Architect, Radim, and Vidas CMV IgG Avidity assays, the cutoff and upper limit of the gray zone for specific IgG avidity were 50 and 60%, 35 and 45%, and 20 and 80%, respectively. ND, not determined.