TABLE 6.

Summary of the seroconversion sensitivities of the Architect, Radim, and Vidas CMV IgG Avidity assays

Assay and time of blood draw after seroconversiona	No. of blood specimens:					Sensitivity (%) by:
	Total	With detectable CMV-specific IgG				Calculation method 1b	Calculation method 2b
		Total	Low avidity	Gray-zone avidity	High avidity
Architect CMV IgG Avidity assay
0-3 mo	35	34	34	0	0	100.0	97.1
0-4 mo	37	36	36	0	0	100.0	97.3
Radim CMV IgG Avidity assay
0-3 mo	35	30	28	1	1	93.3	80.0
0-4 mo	37	32	28	2	2	87.5	75.7
Vidas CMV IgG Avidity assay
0-3 mo	35	31	5	26	0	16.1	14.3
0-4 mo	37	33	5	28	0	15.2	13.5

^aAll the assays tested were able to detect the early stage of seroconversion, since the validity criteria of the Architect (CMV-specific IgG concentration, ≥6.0 AU/ml), Radim (OD, >0.300), and Vidas (CMV-specific IgG concentration in the reference aliquot, ≥6 AU/ml) CMV IgG avidity assays are fulfilled.

^bFor an explanation of the different calculation methods, see Materials and Methods.