Table 1.
Inflammatory response and other immunoregulatory genes and single nucleotide polymorphisms (SNPs) evaluated
| Gene symbol | Gene name | Location | Alias (SNP500 location) | RS no. |
|---|---|---|---|---|
| IL1A | Interleukin 1-α | 2q13 | A114S (Ex5+21G>T), C−889T (Ex1+12C>T) | rs17561*, rs1800587* |
| IL1B | Interleukin 1-β | 2q14 | C−511T, C3954T or F105F, C−31T | rs16944*, rs1143634*, rs1143627* |
| IL1RN | Interleukin 1 receptor antagonist | 2q14.2 | A9589T | rs454078* |
| IL8RB | Interleukin 8 receptor β | 2q35 | (3′-UTR, Ex3+1235T>C), (3′-UTR, Ex3-1010G>A), L262L (Ex3+811C>T) | rs1126579*, rs1126580*, rs2230054* |
| Interleukin 8 | 4q12-q13 | T-251A, (IVS1+230G>T), (IVS1−204C>T) | rs4073*, rs2227307*, rs2227306* | |
| TNF | Tumor necrosis factor | 6p21.3 | G−308A, G−238A, C-857T, A−863C | rs1800629*, rs361525*, rs1799724*, rs1800630† |
| LTA | Lymphotoxin-α | 6p21.3 | A252G C−91A | rs909253*, rs2239704* |
| IL6 | Interleukin 6 | 7p15.3 | G−174C, G−597A or G−598A | rs1800795*, rs1800797* |
| IL16 | Interleukin 16 | 15q25.1 | 3′-UTR, Ex22+871A>G, 3′-UTR, Ex22+889G>T | rs859*, rs11325* |
| VCAM1 | Vascular cell adhesion molecule 1 | 1p32-p31 | T−1591C, K644K (Ex9+149G>A) | rs1041163*, rs3176879* |
| FCGR2A | Receptor for Fc fragment of IgG, low-affinity IIa (CD32) | 1q21-q23 | H165R (Ex4−120A>G) | rs1801274* |
| SELE | Selectin E | 1q22-q25 | S149R (Ex4+24A>C) | rs5361* |
| IL10 | Interleukin 10 | 1q31-q32 | C−819T, C−592A, A−1082G, T−3575A | rs1800871*, rs1800872*, rs1800896*, rs1800890* |
| STAT1 | Signal transducer and activator of transcription 1 | 2q32.2-q32.3 | IVS21−8C>T (splice) | rs2066804* |
| CTLA4 | Cytotoxic T lymphocyte-associated 4 | 2q33 | T17A (Ex1−61A>G) | rs231775* |
| CCR2 | Chemokine, CC motif, receptor 2 | 3p21 | V64I (Ex2+241G>A) | rs1799864* |
| CCR5 | Chemokine, CC motif, receptor 5 | 3p21 | Δ32 | rs333* |
| CX3CR1 | Chemokine, CXC motif | 3p21 | V249I (Ex2+754G>A) | rs3732379* |
| IL12A | Interleukin 12, α | 3q25.33 | G8685A | rs568408* |
| IL2 | Interleukin 2 | 4q26-q27 | Ex2T>G | rs2069762* |
| IL15 | Interleukin 15 | 4q31.21 | 3′-UTR, Ex9−66T>C | rs10833* |
| IL7R | Interleukin 7 receptor (CD127) | 5p13 | V138I (Ex4+33G>A) | rs1494555* |
| IL13 | Interleukin 13 | 5q23.3 | Q144R (Ex4+98A>G), C−1069T | rs20541*, rs1800925* |
| IL4 | Interleukin 4 | 5q31.1 | C−524T, T−1098G, 5′-UTR, Ex1-168C>T | rs2243250*, rs2243248*, rs2070874* |
| IL5 | Interleukin 5 | 5q31.1 | C−745T, C−1551T, Ex4+78C>A | rs2069812*, rs2069807*, rs2069818† |
| IL12B | Interleukin 12B | 5q33.3 | 3′-UTR, Ex8+159A>C | rs3212227* |
| IFNGR1 | Interferon γ receptor 1 | 6q23-q24 | IVS6−4G>A | rs3799488* |
| TLR4 | Toll-like receptor 4 | 9q32-q33 | D299G (Ex4+636A>G) | rs4986790* |
| IL15RA | Interleukin 15 receptor α | 10p15.1 | 3′-UTR, Ex8−361A>C | rs2296135* |
| CXCL12 | Chemokine, CXC motif, ligand 12 (SDF-1) | 10q11.1 | 3′-UTR, Ex4+535C>T | rs1801157* |
| IL10RA | Interleukin 10 receptor α | 11q23.3 | 3′-UTR, Ex7−109G>A | rs9610* |
| IL4R | Interleukin 4 receptor | 16p12.1-p11.2 | C−29429T | rs2107356* |
| JAK3 | Janus kinase 3 | 19p13.1 | 3′-UTR, Ex23+291A>G, IVS2+42G>A, IVS2+40G>A | rs3008*, rs3212713†, rs3212712† |
| ICAM1 | Intercellular adhesion molecule 1 | 19p13.3-p13.2 | K56M (Ex2+100A>T) | rs5491* |
| IFNG | Interferon γ | 21q14 | IVS3+284G>A, C−1615T | rs1861494*, rs2069705* |
| IFNGR2 | Interferon γ receptor 2 | 21q22.1-q22.2 | Q64R (Ex2−16A>G) | rs9808753* |