Table 1.
Genotype | Pathology Status
|
|||||||
---|---|---|---|---|---|---|---|---|
Confirmed CD117+*
|
Confirmed CD117−†
|
Confirmed Non-GIST Sarcoma†
|
Unconfirmed CD117+‡
|
|||||
No. | % | No. | % | No. | % | No. | % | |
KIT 8 | 1 | 0.3 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
KIT 9 | 31 | 8.4 | 0 | 0.0 | 0 | 0.0 | 2 | 5.6 |
KIT 11 | 269 | 73.1 | 6 | 60.0 | 0 | 0.0 | 19 | 52.7 |
KIT 13 | 3 | 0.8 | 0 | 0.0 | 0 | 0.0 | 2 | 5.6 |
KIT 17 | 4 | 1.1 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
PDGFRA 12 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 1 | 2.8 |
PDGFRA 18 | 4 | 1.1 | 2 | 20.0 | 1 | 7.1 | 1 | 2.8 |
WT | 56 | 15.2 | 2 | 20.0 | 13 | 92.9 | 11 | 30.6 |
Total | 368 | 10 | 14 | 36 |
Abbreviations: GIST, gastrointestinal stromal tumor; KIT 8, mutation of KIT exon 8; WT, wild type (no mutation of KIT or PDGFRA).
Five patients were ineligible (3, KIT 11; 1, KIT 9; 1, PDGFRA 18).
All patients were otherwise eligible except for pathology review.
Two patients were ineligible (both with KIT 11 mutations).