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Correlation of Imatinib Dose and Tumor Genotype With TTP and OS
| Genotype | Treatment Arm | No. of Patients | TTP (months) | OS (months) |
|---|---|---|---|---|
| Exon 11 | IM400 | 141 | 27.2 | 60.0 |
| Exon 11 | IM800 | 142 | 23.9 | NR |
| KIT exon 9 | IM400 | 14 | 9.4 | 38.6 |
| KIT exon 9 | IM800 | 18 | 18.0 | 38.4 |
| WT | IM400 | 43 | 15.6 | 49.0 |
| WT | IM800 | 24 | 9.8 | 39.5 |
Abbreviations: TTP, time to progression; OS, overall survival; IM400, imatinib 400 mg daily; IM800, imatinib 800 mg daily; NR, not reached; WT, wild type.
