Table A4.

Univariate and Multivariate Analysis of Cofactors Associated With OS

Cofactor	Analysis of OS
	Univariate			Multivariate
	P	HR	95% CI	P	HR	95% CI
KIT mutation
Exon 9	.014	1.79	1.13 to 2.85	.002	2.28	1.36 to 3.84
WT	.049	1.46	1.00 to 2.13	.0003	2.08	1.40 to 3.10
Treatment*	.96	1.01	0.75 to 1.35	.65	1.07	0.79 to 1.46
Sex, male	.035	1.39	1.02 to 1.87	.003	1.65	1.18 to 2.25
Age, by decades	.00038	1.23	1.09 to 1.39	.00006	1.28	1.14 to 1.45
Zubrod performance†	9 × 10−13	3.63	2.55 to 5.17	8.6 × 10−9	3.40	2.24 to 5.15
ANC	7.5 × 10−9	1.16	1.11 to 1.23	.044	1.07	1.00 to 1.14
HGB	7.6 × 10−5	0.84	0.77 to 0.92	.023	0.90	0.82 to 0.99
Primary tumor type‡	.65	1.07	0.79 to 1.46	.11	1.31	0.94 to 1.82

Abbreviations: OS, overall survival; HR, hazard ratio; WT, wild type; ANC, absolute neutrophil count; HGB, hemoglobin

^*Treatment of imatinib 400 mg/d v 800 mg/d.

^†Performance score of 0 to 1 v 2 to 3.

^‡Gastric v nongastric tumor type.