Figure 1.

Cluster analysis of 470 genes that changed >2-fold and had at least one mean intensity value of 100 in at least one of the experimental conditions. The data are presented as a ratio of the mean of the average intensities from all animals in each experimental group. Genes that were present at higher levels in the examined group (increased) are shown in progressively brighter shades of red, depending on the fold difference, and genes that were expressed at lower levels are shown in progressively brighter shades of green. Genes shown in black were not different between the two groups being compared. Columns identify the pair-wise comparison being made between wild-type (WT) or β6^−/− (KO) mice examined at baseline (Bs) or at 7 days (7d) or 14 days (14d) after treatment with intratracheal bleomycin. Baseline values included both untreated mice (n = 4) and mice sacrificed 7 days after treatment with intratracheal saline (n = 3). All other values were the mean of three average intensities. Cluster analysis was performed on log transformed values of the fold ratios with gene cluster and presented with treeview. The letters on the right define distinct clusters that are discussed in the text or presented in the following figures or on our web site.