Table 2.

B cells in IRI

Publication, year	Organ/Species	IR Model	Findings
Weiser et al [89], 1996	Skeletal Muscle Mouse	Warm	IgG-, C3-, or C4-deficient mice protected from injury; WT serum transfer restores injury.
Burne-Taney et al [83], 2003	Kidney Mouse	Warm	B cell–deficient mice (mu MT) protected from injury; serum transfer partially restored injury, but B-cell transfer alone does not restore injury.
Austen et al [85], 2004	Skeletal Muscle Mouse	Warm	Cr2 gene knockout (KO) mice are protected from injury; B-cell transfer with CM22 and WT serum transfer restores injury.
Zhang et al [82], 2004	Intestine Mouse	Warm	RAG1 KO protected from injury; B-cell transfer with CM22 restores injury.
Chan et al [93], 2006	Skeletal Muscle Mouse	Warm	Binding of preformed IgM clone necessary for IRI; specific peptide blockade of IgM clone attenuates injury.
Zhang et al [87], 2006	Heart Mouse	Warm	Cr2 KO mice protected from injury; WT IgM transfer restored myocardial reperfusion injury.
Busche et al [30], 2007	Heart Mouse	Not Listed	IgM/ MBL KO mice reconstituted with IgM/MBL KO plasma had significantly less injury compared to IgM/MBL KO mice reconstituted with WT plasma and WT mice reconstituted with WT plasma