Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Feb 11;106(9):3408–3413. doi: 10.1073/pnas.0805323106

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 4. — Stimulated 5-HT release and intracellular Ca²⁺ in RIN14B cells. Ionomycin (10 μM) induced the release of 5-HT from RIN14B cells (A). The dose-response curves of TRPA1 agonist-induced increase in [Ca²⁺]_i in RIN14B cells (B). Blockade of the AITC (30 μM)-evoked increase in [Ca²⁺]_i induced by ruthenium red (3 μM) in RIN14B cells (C). TRPA1 agonist-induced release of 5-HT from RIN14B cells (D). Effects of the TRPA1 inhibitor ruthenium red (30 μM) on the AITC (300 μM)- or CA (300 μM)-induced 5-HT release from RIN14B cells (E). Role of Ca²⁺ in the TRPA1 agonist-induced release of 5-HT from RIN14B cells (F). The cells were stimulated by AITC (300 μM) or CA (300 μM) in HBSS (open column) and Ca²⁺-free HBSS (solid column). All data represent the mean ± S.D. (n = 3). **, P < 0.01; ***, P < 0.001 vs. control group (Dunnett's test for D and Student's t test for A, C, E, and F).