Table 2.
Cardiac weights and echocardiographic measurements in lean (+/+) and obese (fa/fa) ZDF rats at 20 weeks of age
| Rats | n | Weights
|
Echocardiography
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Body weight, g | Heart weight, g | RV weight, g | LV weight, g | LV end-diastolic diameter, mm | LV end-systolic diameter, mm | Septal wall thickness, mm | Posterior wall thickness, mm | Fractional shortening, % | Fractional area shortening, % | ||
| Lean wild type (+/+) | 3 | 394 ± 6 | 1.20 ± 0.01 | 0.20 ± 0.01 | 0.85 ± 0.01 | 7.3 ± 0.3 | 4.2 ± 0.4 | 1.6 ± 0.1 | 1.9 ± 0.1 | 43 ± 6 | 65 ± 8 |
| Obese ZDF (fa/fa) | 8 | 572 ± 24* | 1.55 ± 0.17 | 0.25 ± 0.02 | 1.06 ± 0.01 | 7.8 ± 0.7 | 5.0 ± 0.8* | 1.6 ± 0.1 | 1.7 ± 0.2 | 36 ± 7* | 56 ± 9* |
| TGZ-treated (fa/fa) | 6 | 611 ± 7† | 1.78 ± 0.29 | 0.24 ± 0.02 | 1.04 ± 0.02 | 7.6 ± 0.5 | 4.0 ± 0.6† | 1.6 ± 0.1 | 1.8 ± 0.2 | 48 ± 7† | 69 ± 7† |
RV, right ventricle; LV, left ventricle.
*P < 0.05, untreated obese (fa/fa) vs. lean (+/+) rats.
†P < 0.05, TGZ-treated obese (fa/fa) vs. untreated obese (fa/fa) rats.