Fig. 4.

p48-Kras mice are hypermetabolic and display increased energy uptake in the pancreas. (A–D) p48-Kras mice and Kras control littermates on a HFD were housed in metabolic chambers and (A) VO₂ consumption, (B) VCO₂ production, (C) respiratory exchange rate (RER), and (D) heat production (HP) were measured over 24 h (12-h light and 12-h dark cycle). (E) [¹⁸F]-FDG uptake in p48-Kras mice and control littermates was monitored by positron emission tomography (PET). Data are mean values ± SEM. n = 4–6 mice per genotype. *, P ≤ 0.05.