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Cry1−/−/Cry2−/− mouse on methamphetamine (MA). Double-plotted actograms from an intact Cry1−/−/Cry2−/− mouse before methamphetamine treatment (A) and during the last 2 weeks of drug treatment (B). This animal had no significant free-running period in DD before drug administration but takes on a long free-running period in the presence of 0.005% methamphetamine, as shown in the periodogram (C). A significant peak is observed at 29.17 h.
