Table 2. Adjusted association between breast cancer (overall and by ER status) and SARD conditions.
|
All cases–control (N=84 778)
|
ER-positive cases–control (N=56 296)
|
ER-negative cases–control (N=9991)
|
||||
|---|---|---|---|---|---|---|
| SARD | N | OR (95% CI)a | N | OR (95% CI)a | N | OR (95% CI)a |
| None | 81 745 | Reference | 54 343 | Reference | 9627 | Reference |
| Any | 3033 | 0.88 (0.84–0.93)b | 1953 | 0.85 (0.80–0.90)b | 364 | 0.91 (0.81–1.02) |
| By condition | ||||||
| Rheumatoid arthritis | 2444 | 0.87 (0.82–0.92)b | 1554 | 0.83 (0.78–0.89)b | 301 | 0.91 (0.81–1.04) |
| Systemic lupus | 172 | 0.99 (0.78–1.24) | 128 | 1.08 (0.85–1.40) | 10 | 0.49 (0.26–0.94)b |
| Sjogren's syndrome | 196 | 1.06 (0.85–1.32) | 130 | 1.04 (0.82–1.33) | 21 | 1.01 (0.64–1.61) |
| Systemic sclerosis | 64 | 0.96 (0.65–1.44) | 42 | 0.93 (0.60–1.43) | 7 | 0.88 (0.39–1.98) |
| Dermatomyositis | 14 | 0.76 (0.35–1.65) | 10 | 0.80 (0.35–1.85) | <5 | 0.99 (0.22–4.36) |
| Multiple SARDs | 143 | 0.78 (0.61–0.99)b | 89 | 0.71 (0.54–0.94)b | 23 | 1.09 (0.70–1.71) |
a
Odds ratios (ORs) and 95% confidence intervals (CIs) are adjusted for age, year of selection, race, mammography, region of residence, income, and immunosuppressive therapy.
b
P<0.05.