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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Pediatr Res. 2008 Oct;64(4):326–333. doi: 10.1203/PDR.0b013e31818535e8

Figure 2. Migration and patterning in the chick ENS.

Figure 2

Vagal-derived ENCCs migrate proximodistally along the intestine, as shown schematically at different developmental stages (A). Hu-labeled whole-mount demonstrates the wavefront of enteric neurons at the level of the ceca at E6.5 (B, arrowhead, magnified in inset). At E8, colorectal colonization is complete (C). HNK-1-labeled cross-section through an E8 distal colorectum (D) at the level marked in (C) reveals the submucosal (smp) and myenteric (mp) plexuses, and the Nerve of Remak (NoR). The epithelium (ep) is labeled for orientation. umb.=umbilicus