Figure 4. Simulation of a knock-out in silico experiment (IkBa^−/−).

Manipulating the model so that there is no de novo transcriptional synthesis of NF-kB inhibitor (IkBa) which is responsible for the absence of NF-kB auto-regulatory feedback loop. Such a scenario accounts for maladapted activity of NFkBn that triggers an uncompensated inflammatory response.