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. 2007 Feb;37(2):487–500. doi: 10.1002/eji.200636503

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Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Proliferation and apoptosis of Rag1^–/– foetal and adult DN thymocytes. (A) Percentages of DN3 (open bars) and DN4 (shaded bars) Rag1^–/– cells positive for high expression of cyclin B1 in thymi at E14.5, E15.5, E16.5 and, E17.5 and adult thymus. Bars represent data from at least three animals and error bars are shown. (B) Ratio of proliferation of DN3 relative to DN4 cells as in (A). (C) Intracellular expression of the active form of caspase-3 in DN3 (open histograms) and DN4 (shaded histograms) subsets of Rag1^–/– E15.5, E16.5, E17.5 and adult thymocytes. Percentages of caspase-3-positive cells are shown. (D) Mean percentages of active caspase-3-positive DN3 (open bars) and DN4 (shaded bars) E15.5, E16.5, E17.5 and adult thymocytes. Bars represent data from at least three animals and error bars are shown.