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. 2008 Aug 12;19(4):745–759. doi: 10.1093/cercor/bhn123

Figure 6.

Figure 6.

Expression of secreted factor Tgfα at E13.5 and E15.5. Tgfα is expressed in the VP and basal telencephalon at E13.5 (A, E, arrow). In Gsh2 mutants, VP expression is expanded ventrally (arrowheads) and basal expression is maintained (arrow) (B, F). In Sey mutants, VP expression is missing (asterisks) whereas basal expression is unaffected (arrows, C, G). VP expression remains absent in Sey/Gsh2 double mutants (asterisks), though basal expression is present (arrows) (D, H). At E15.5, expression is observed in the VP and differentiating striatum (STR, arrows) (I, M). In Gsh2 mutants, VP expression is expanded (arrowheads), and a putative ectopic basal migration is observed (empty arrowheads). A smaller domain of expression is observed in the striatum (J, N, arrows). In Sey mutants, VP expression is missing (asterisks), although striatal expression remains (arrows) (K, O). In Sey/Gsh2 double mutants, expression at the VP is not restored (asterisks), and remains present in the striatum (arrows) (L, P). n numbers are as follows: controls, n= 4 [E13.5], n= 4[E15.5]; Gsh2−/−, n= 3 [E13.5], n= 3 [E15.5]; Sey/Sey, n= 3 [E13.5], n= 4 [E15.5]; Sey/Sey;Gsh2−/−, n= 3 [E13.5], n= 3 [E15.5]. Scale bar: 200 μm.