Figure 1.

Effect of CA on blood disappearance in vivo. BALB/c mice (n = 3/group) were injected at t = 0 with 400 μg ¹²⁵I-NR-LU-10/SA conjugate. Blood samples (10 μl, n = 2/time point) were serially removed from the retroorbital plexus and assayed for radioactivity. At 28.5 hr, mice were injected with either saline (●) or 200 μg of CA (■). For the CA mice, blood was sampled at 28.5 (preinjection), 29, 29.5, 30.5, 32.5, 34.5, 35.5, 39.5, 50, and 114 hr. Control animals were sampled at t = 0.17, 0.5, 1.0, 2.0, 4.0, 28.5, 50.0, 72.0, 96.0, and 168 hr. Data are presented as the mean % i.d. in total blood +/− SD of each group.