Figure 3.

Projected radioactivity concentrations resulting from either ⁹⁰Y-NR-LU-10 whole antibody or pretargeted ⁹⁰Y-DOTA-biotin. Tumor uptake (■) and blood clearance (●) data from Table 1 (mean %i.d./g of tissue) were used to calculate the decay-corrected radioactivity concentration after administration of either 200 μCi ⁹⁰Y-NR-LU-10 whole antibody (A) or 800 μCi pretargeted ⁹⁰Y-DOTA-biotin (B). Data are presented as μCi of ⁹⁰Y/g of tissue +/− SD at 2, 24, 48, and 120 hr postinjection. AUC values were calculated by using trapezoidal integration from 0 hr to 120 hr postinjection from the data in Table 1. T/B, tumor to blood.