Figure 5.

Hematologic toxicity resulting from either ⁹⁰Y-NR-LU-10 whole antibody or pretargeted ⁹⁰Y-DOTA-biotin. Leukocyte toxicity was measured in separate groups of BALB/c female mice (n = 10) at weekly intervals postinjection. (A) On day −1, mice received (i.v.) either saline (●) or 100 μCi (■), 200 μCi (▴), or 300 μCi (▾) of ⁹⁰Y-NR-LU-10 whole antibody. (B) On day −1, mice received (i.v.) 400 μg NR-LU-10/SA, followed on day 0 by 200 μg of CA and either saline (●) or 200 μCi (■), 400 μCi (▴), or 800 μC_i (▾) of pretargeted ⁹⁰Y-DOTA-biotin. Specific activities of radiolabeled reagents were varied, with total mass dose held constant. Data are presented as the mean ± SD percent of initial leukocyte values.