Table 1.
Baseline characteristics and bone mineral density measures (mean ± SD, N (%)) by prostate cancer status in the MrOS cohort
| Incident prostate cancer (N= 255) |
No prostate cancer (N= 4342) |
P-value | |
|---|---|---|---|
| Age at baseline | 72.4 ± 5.1 | 73.2 ± 5.8 | 0.02 |
| Age at diagnosis of prostate cancer | 75.4 ± 5.3 | - | |
| Race | 0.88 | ||
| White | 229 (89.8) | 3864 (89.0) | |
| African American | 12 (4.7) | 176 (4.0) | |
| Asian | 7 (2.8) | 147 (3.4) | |
| Hispanic | 4 (1.6) | 102 (2.3) | |
| Other | 3 (1.2) | 53 (1.2) | |
| Educational level | |||
| College or higher | 130 (51.0) | 2285 (52.6) | 0.61 |
| Smoking status | 0.20 | ||
| Current smoker | 7 (2.6) | 169 (3.9) | |
| Past smoker | 141 (55.3) | 2574 (59.3) | |
| Alcohol consumption | 173 (68.4) | 2799 (64.5) | 0.21 |
| (% who had12 drinks in past month) | |||
| Physical activity (PASE score) | 159.8 ± 72.7 | 148. ± 68.1 | 0.007 |
| Weight (kg) | 82.2 ± 12.3 | 83.3 ± 13.4 | 0.20 |
| Height (cm) | 174.1 ± 6.8 | 174.2 ± 6.8 | 0.77 |
| BMI (Kg/m2) | 27.1 ± 3.5 | 27.4 ± 3.8 | 0.21 |
| Weight change since age 25 (Kg) | 10.2 ± 10.8 | 10.3 ± 11.4 | 0.88 |
| Calcium intake from diet and supplements (mg/day) | 1197.3 ± 575.3 | 1108.6 ± 581.8 | 0.02 |
| Vitamin D intake from diet and supplements (IU/day) | 409.7 ± 240.5 | 384.3 ± 244.1 | 0.11 |
| Family History of prostate cancer | 48 (18.8) | 557 (12.8) | 0.006 |
| Medical History | |||
| History of osteoporosis | 6 (2.4) | 73 (1.7) | 0.45 * |
| History of diabetes | 22 (8.6) | 479 (11.0) | 0.23 |
| History of prostatitis | 61 (23.9) | 862 (19.8) | 0.11 |
| Medications | |||
| Thiazide diuretics | 32 (12.6) | 470 (10.8) | 0.39 |
| Oral corticosteroids | 1 (0.4) | 69 (1.6) | 0.18 * |
| Statins | 78 (30.6) | 1101 (25.4) | 0.06 |
| Histologic Grade | |||
| Low (Gleason sum 2–6) | 122 (47.8) | - | |
| High (Gleason sum ≥7) | 129 (50.6) | ||
| Unknown | 4 (1.6) | ||
| Total Body BMD (g/cm2) † | 1.16 ± 0.12 | 1.18 ± 0.12 | 0.05 |
| Total hip BMD (g/cm2) ‡ | 0.96 ± 0.14 | 0.96 ± 0.14 | 0.81 |
| Spine BMD (g/cm2) § | 1.06 ± 0.17 | 1.08 ± 0.18 | 0.29 |
*
P-value for Fisher’s Exact test
†
Total body BMD is missing for 28 participants.
‡
Hip BMD is missing for 1 participant.
§
Spine BMD is missing for 5 participants.