Table 5.

Risk of high grade and low grade prostate cancer by baseline total body, total hip, and spine BMD quartiles in the MrOS cohort

	High Grade PCa (Gleason sum ≥7)		Low Grade PCa (Gleason sum 2–6)
	Number at risk (events)	Multivariate hazard ratio (95% CI) *	Number at risk (events)	Multivariate hazard ratio (95% CI) *
Total body BMD (g/cm2)
First Quartile	1111 (41)	1.00	1100 (30)	1.00
Second Quartile	1100 (27)	0.64 (0.40–1.04)	1113 (40)	1.23 (0.76–1.98)
Third Quartile	1115 (39)	0.93 (0.60–1.44)	1103 (27)	0.85 (0.50–1.43)
Fourth Quartile	1117 (21)	0.43 (0.25–0.74) †	1121 (25)	0.79 (0.46–1.36)
P-value for trend		0.01		0.21
Total hip BMD (g/cm2)
First Quartile	1125 (40)	1.00	1108 (23)	1.00
Second Quartile	1108 (22)	0.54 (0.32–0.92) ‡	1125 (39)	1.67 (0.99–2.82)
Third Quartile	1119 (37)	0.86 (0.54–1.38)	1111 (29)	1.28 (0.73–2.24)
Fourth Quartile	1118 (30)	0.63 (0.38–1.06)	1119 (31)	1.41 (0.80–2.50)
P-value for trend		0.21		0.46
Spine BMD (g/cm2)
First Quartile	1121 (29)	1.00	1118 (26)	1.00
Second Quartile	1115 (40)	1.40 (0.87–2.26)	1108 (33)	1.26 (0.75–2.13)
Third Quartile	1108 (30)	1.03 (0.62–1.72)	1116 (38)	1.59 (0.96–2.62)
Fourth Quartile	1123 (29)	0.91 (0.54–1.54)	1118 (24)	1.07 (0.61–1.87)
P-value for trend		0.43		0.51

^*Adjusted for age, race, BMI, family history of prostate cancer, physical activity, statin use, and calcium intake

^†p <0.01

^‡p <0.05