Skip to main content
. Author manuscript; available in PMC: 2010 Feb 19.
Published in final edited form as: Org Lett. 2009 Feb 19;11(4):827–830. doi: 10.1021/ol802828d

Table 1.

Preliminary Trials Using Strain-Release Silacyclesa

graphic file with name nihms90271f6.jpg
entry R1 R2 mol %Er(OiPr)3 % yield 7 (8)b time (min)
(silacycle)
1 Me H (6a) 5 50 (32) 5
2 iPr H (6b) 5 50 (28) 40
3 Me Me (6c) 5 62 (3) 60
4 Me Me (6c) 10 84 (6) 30
5 Me Me (6c) 1 trace 120
a

Conditions: 1.5 equiv of PhCHO, 2.0 equiv of 6, [1]0 = 0.2 M.

b

Yields determined by 1H NMR versus an internal standard.