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Diagram of retroviral gene trap constructs. (A) Schematic of how gene traps create mutations after integration. As an example, integration of a proviral gene trap between exons 1 and 2 leads to loss of exons 2 and 3. (B) Diagrams of PGGV2-PGGV7 are depicted. Grey bars in PGGV5-7 represent unique insertion in LTR. The titer for each construct is shown to the right. SA, splice acceptor; LacZ, beta-galactosidase; Neo, neomycin resistance marker; PolA, polyadenylation.
