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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Surg Res. 2008 Apr 28;150(1):137–143. doi: 10.1016/j.jss.2008.03.047

Figure 6.

Figure 6

Proposed mechanism of action of pancreatic reg I on ductal and β-cells. Exogenous reg I binds the EXTL3 receptor and induces cell growth via signal transduction through JNK and cyclin D1. Intracellular reg I, however, can inhibit cell growth by direct interaction with MKP-1, inducing a pathway other than mitogenesis (dotted line represents cell membrane).