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. 2009 Mar 5;106(12):4584–4590. doi: 10.1073/pnas.0900774106

Fig. 8.

Fig. 8.

Location of the N-terminal phosphorylation sites and autoubiquitination sites in the structure of Pellino 1. A homology model of Pellino 1 was generated based on the recently published structure of Pellino 2 (30) using the program Modeller (37). Ser-76, Ser-78, Thr-80, Ser-82, and Thr-86 of Pellino 1 (shown in red) are located in a region of antiparallel β-sheet, termed the wing (turquoise), which is an appendage of the cryptic FHA domain (blue) thought to interact with phosphorylated IRAK1. Lys-169 and Lys-202 of Pellino 1, which were detected as sites of autoubiquitination, are also shown in red.