Table 7.

NGF signaling network.

Upstream node	Downstream node	Sign of interaction
Ras	Raf	+
Raf	MEK1/2	+
MEK1/2	Erk1/Erk2	+
Erk1/Erk2	Rsk	+
Rsk	CREB	+
CREB	FasL/Bcl-2/Bax/Egr-1 mRNA	+
p38	FasL/Bcl-2/Bax/Egr-1 mRNA	+
Akt1/2	FasL/Bcl-2/Bax/Egr-1 mRNA	+
Forkhead	FasL/Bcl-2/Bax/Egr-1 mRNA	+
NFκB	FasL/Bcl-2/Bax/Egr-1 mRNA	+
Trk receptor	PLCγ	+
PLCγ	IP3/DAG complex	+
IP3/DAG complex	PKCδ	+
PKCδ	MEK1/2	+
Frs2/Crk/DOCK-180/SH2B/Grb2 complex	Rac	+
Trk receptor	IRS-1	+
IRS-1	Shc/Grb2/SOS/Gab/PI3k complex	+
Shc/Grb2/SOS/Gab/PI3k complex	1	+
Shc/Grb2/SOS/Gab/PI3k complex	Akt1/2	+
PDKs	Akt1/2	+
Akt1/2	p38	-
Akt1/2	Forkhead	-
Akt1/2	NFκB	+
Akt1/2	BAD/Bcl-2 complex	+
BAD/Bcl-2 complex	Bad/14-3-3 complex	+
Ras	Shc/Grb2/SOS/Gab/PI3k complex	+
Shc/Grb2/SOS/Gab/PI3k complex	MEK1/2	+
Trk receptor	Frs2/Crk/DOCK-180/SH2B/Grb2 complex	+

This table shows the connections that comprise the topology of the NGF signaling network.