Table 4.
Targets in the H-List that are also involved in drug resistance mechanisms.
| Resistance related proteins | |
| Protein | Description |
| CcdA (Rv0527) | Cytochrome |
| PolA (Rv1629) | SOS |
| LldD2 (Rv1872c) | Cytochrome |
| QcrC (Rv2194) | Cytochrome |
| QcrB (Rv2196) | Cytochrome |
| CtaC (Rv2200c) | Cytochrome |
| Cyp121 (Rv2276) | Cytochrome |
| Rv3660c (Rv3660c) | HGT |
| Proteins closely connected to resistance proteins | |
| Protein | Closely connected to |
| SecY (Rv0732) | DnaE1 (SOS) and SecA1 and SecA2 (HGT) |
| Rv0843 (Rv0843) | Three cytochrome proteins |
| Pdc (Rv0853c) | Rv1988 (Antibiotic Efflux Pump) and two cytochromes |
| Rv1456c (Rv1456c) | Three cytochrome proteins |
| Rv1711 (Rv1711) | RecA, DnaE1 (SOS proteins) and a cytochrome |
| Rv1828 (Rv1828) | SecA2 (HGT) and two cytochromes |
| QcrC (Rv2194) | Four cytochrome proteins |
| QcrA (Rv2195) | Five cytochrome proteins |
| QcrB (Rv2196) | Five cytochrome proteins |
| CtaC (Rv2200c) | Five cytochrome proteins |
| Cyp121 (Rv2276) | 19 cytochrome proteins |
| HemE (Rv2678c) | Seven cytochrome proteins |
| FtsK (Rv2748c) | SOS proteins RecA, PolA and DnaE1 |
| RnhB (Rv2902c) | SOS proteins PolA, DnaE1 and DnaE2 |
| TrmD (Rv2906c) | SOS proteins PolA, DnaE1 and Rv2294 (Antibiotic Efflux Pump) |
| PrfB (Rv3105c) | PolA (SOS) and SecA1 and SecA2 (HGT) |
| IlvX (Rv3509c) | Three cytochrome proteins |
| TrxB2 (Rv3913) | RecA (SOS) and two cytochrome proteins |
The top panel shows targets that are directly implicated in resistance mechanisms. The lower panel indicates targets which are immediately connected to proteins involved in the emergence of resistance in the interactome. These proteins are predicted to be involved in mediating the flow of information from the targets to the resistance machinery.