Table 1.
Changes* in body weight, waist, leptin, fat, total cholesterol, LDL cholesterol, glucose and adiponectin measurements in the course of the study.
| Time (weeks) | ||||||
| Variables | Group | Base line | 4 | 8 | 10 | Over change |
| Weight (Kg) | Placebo | 96.4 ± 12.3 | 95.8 ± 8.2 | 95.1 ± 10.6 | 95.7 ± 15.2 | -0.7 |
| IGOB131 | 97.9 ± 9.1 | 94.3 ± 5.5 a | 89.7 ± 4.7 a | 85.1 ± 3.1b | -12.8 | |
| Waist (cm) | Placebo | 106.4 ± 10.8 | 102.7 ± 10.6 | 101.1 ± 14.8 | 101.1 ± 15.8b | -5.3 |
| IGOB131 | 105.1 ± 6.3 | 98.0 ± 8.4a | 90.1 ± 8.70a | 88.1 ± 7.6 | -16.19 | |
| Leptin (ng/ml) | Placebo | 31.3 ± 1.8 | 29.4 ± 1.4 | 28.1 ± 1.8 | 28.4 ± 1.8 | -2.9 |
| IGOB131 | 32.9 ± 1.6 | 18.1 ± 1.3a | 16.8 ± 1.2a | 16.9 ± 1.3b | -16.0 | |
| Fat (%) | Placebo | 34.7 ± 8.6 | 33.31 ± 10.9 | 32.9 ± 11.9 | 32.7 ± 15.7 | -1.99 |
| IGOB131 | 34.2 ± 7.9 | 31.6 ± 5.4a | 28.2 ± 6.6a | 27.9 ± 5.5a | -6.3 | |
| LDL cholesterol (mg/dL) | Placebo | 77.4 ± 9.2 | 76.5 ± 8.9 | 74.1 ± 9.3 | 73.7 ± 8.3 | -3.75 |
| IGOB131 | 82.2 ± 8.1 | 71.8 ± 5.9b | 64.7 ± 8.9b | 59.8 ± 5.0b | -22.44 | |
| Total cholesterol (mg/dL) | Placebo | 145.2 ± 22.4 | 143.9 ± 12.2 | 142.1 ± 13.6 | 142.4 ± 12.1 | -2.8 |
| IGOB131 | 151.7 ± 18.5 | 133.7 ± 16.6a | 120.1 ± 11.9 a | 111.9 ± 5.8a | -39.8 | |
| C-reactive protein (mg/L) | Placebo | 1.46 ± 0.05 | 1.46 ± 0.04 | 1.445 ± 0.03 | 1.455 ± 0.05 | -0.01 |
| IGOB131 | 1.49 ± 0.041 | 0.91 ± 0.05a | 0.71 ± 0.04b | 0.72 ± 0.05b | -0.78 | |
| Glucose (mg/dL) | Placebo | 81.4 ± 9.6 | 79.5 ± 10.1 | 77.8 ± 9.4 | 77.1 ± 7.8 | -4.3 |
| IGOB131 | 85.55 ± 5.59 | 76.6 ± 10.3a | 68.7 ± 9.3a | 66.3 ± 4.9a | -19.3 | |
| Adiponectin (mg/L) | Placebo | 12.1 ± 3.2 | 15.2 ± 3.5 | 14.6 ± 3.5 | 14.94 ± 3.9 | + 2.8 |
| IGOB131 | 12.2 ± 3.0 | 24.8 ± 3.8a | 31.0 ± 4.0b | 31.6 ± 3.9a | + 19.4 | |
a P < 0.05; b P < 0.01 compared with Placebo