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. 2007 Apr 4;13:534–544.

Table 3. MYOC polymorphisms: summary of genetics data for parents and tests of association by family-based association testing under different genetic models in 162 nuclear families.

Marker
 rs2075537
 NGA17
 rs235920
 rs7523603
Allele
 1 (G)
 2 (T)
 3 (13)
 4 (14)
 5 (15)
 6 (16)
 1 (T)
 2 (C)
 1 (A)
 2 (G)
Freq in parents
 0.5633
 0.4367
 0.5015
 0.1836
 0.3117
 0.0031
 0.5355
 0.4645
 0.7562
 0.2438
FBAT - Additive model
No. of families
 125
 125
 123
 74
 107
 2
 121
 121
 91
 91
Z score
 -0.45
 0.45
 1.34
 1.56
 -2.59
 -
 -1.09
 1.09
 1.21
 -1.21
p value
 0.6526
 0.6526
 0.1797
 0.12
 0.0097
 -
 0.2774
 0.2774
 0.2283
 0.2283
Global stat.
 chi2(1)=0.203
 chi2(3)=11.733
 chi2(1)=1.180
 chi2(1)=1.452
p=0.6526
 p=0.0084
 p=0.2774
 p=0.2283
FBAT - Dominant model
No. of families
 70
 95
 82
 73
 94
 2
 79
 88
 32
 78
Z score
 -0.21
 0.45
 0.87
 1.46
 -2.47
 -
 -0.97
 0.7
 1.65
 -0.52
p value
 0.8316
 0.6528
 0.3843
 0.1455
 0.01443
 -
 0.3316
 0.4838
 0.09945
 0.6004
Global stat.
 chi2(2)=0.225
 chi2(3)=7.366
 chi2(2)=1.243
 chi2(2)=2.85
p=0.8934
 p=0.0611
 p=0.5372
 p=0.2405
FBAT - Recessive model
No. of families
 95
 70
 83
 18
 38
 0
 88
 79
 78
 32
Z score
 -0.45
 0.21
 1.17
 0.76
 -1.19
 -
 -0.7
 0.97
 0.52
 -1.65
p value
 0.6528
 0.8316
 0.2438
 0.4477
 0.233
 -
 0.4838
 0.3316
 0.6004
 0.0995
Global stat.
 chi2(2)=0.225
 chi2(3)=3.212
 chi2(2)=1.243
 chi2(2)=2.85
p=0.8934
 p=0.3601
 p=0.5372
 p=0.2405
Marker
 NGA19
 rs2421853
 rs235858
Allele
 1 (11)
 3 (13)
 4 (14)
 5 (15)
 6 (16)
 7 (17)
 1 (C)
 2 (T)
 1 (T)
 2 (C)
Freq in parents
 0.0015
 0.2176
 0.0077
 0.7114
 0.0602
 0.0015
 0.7299
 0.2701
 0.6003
 0.3997
FBAT - Additive model
No. of families
 1
 96
 5
 115
 32
 1
 102
 102
 109
 109
Z score
 -
 -3.03
 -
 2.1
 1.13
 -
 -3.32
 3.32
 4.6
 -4.6
p value
 -
 0.0024
 -
 0.0353
 0.2579
 -
 0.0009
 0.0009
 0.000004
 0.000004
Global stat.
 chi2(3)=10.162
 chi2(1)=11
 chi2(1)=21.146
p=0.0172
 p=0.0009
 p=4.0E-6
FBAT - Dominant model
No. of families
 1
 91
 5
 42
 32
 1
 26
 95
 54
 87
Z score
 -
 -2.28
 -
 2.83
 0.93
 -
 -1.8
 2.97
 2.92
 -3.9
p value
 -
 0.0224
 -
 0.0047
 0.3519
 -
 0.0725
 0.003
 0.0035
 0.000096
Global stat.
 chi2(3)=12.711
 chi2(2)=11.011
 chi2(2)=21.165
p=0.0053
 p=0.0041
 p=2.5E-5
FBAT - Recessive model
No. of families
 0
 28
 0
 107
 1
 0
 95
 26
 87
 54
Z score
 -
 -2.53
 -
 0.92
 -
 -
 -2.97
 1.8
 3.9
 -2.92
p value
 -
 0.0113
 -
 0.3576
 -
 -
 0.003
 0.0725
 0.000096
 0.0035
Global stat.
 chi2(2)=6.837
 chi2(2)=11.011
 chi2(2)=21.165
p=0.0328 p=0.0041 p=2.5E-5

The polymorphisms are shown in order from the 5' end to the 3' end of the MYOC gene: the first four markers in the top part and the last three markers in the bottom part (See Figure 1 for details). For single nucleotide polymorphisms, the major allele was designated as 1 and minor allele as 2, with the identities of the alleles shown within brackets. For microsatellites, four alleles were found for NGA17 and six alleles for NGA19, with the number of GT repeats shown within brackets. "No. of families" refers to the number of informative families in which there was at least one heterozygous parent while "-" indicates that the corresponding value was not calculated because the number of informative families was less than 10. The degree of freedom (n) is shown within brackets after chi2: χ2(n), where n=1, 2, or 3.